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Updated: Dec 6, 2025

Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test
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Physiological and Behavioral Responses to Vocalization Playback in Mice.

Alexandra C Niemczura1,2, Jasmine M Grimsley1,2, Chae Kim1

  • 1Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, United States.

Frontiers in Behavioral Neuroscience
|October 9, 2020
PubMed
Summary

Mouse vocalizations impact listeners differently based on sex and call type. Different call categories trigger distinct physiological and behavioral responses, suggesting varied communication functions in mice.

Keywords:
anxietycommunicationcorticosteronelow frequencymousestressultrasonicvocalization

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Last Updated: Dec 6, 2025

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Area of Science:

  • Animal Behavior
  • Bioacoustics
  • Neuroethology

Background:

  • Mouse social vocalizations are crucial for communication.
  • Previous playback studies focused on single vocalization types or limited listener demographics.
  • Understanding listener responses is key to deciphering vocal communication functions.

Purpose of the Study:

  • To investigate the effects of different mouse vocalization categories on listeners of both sexes.
  • To determine if distinct vocal categories elicit differential physiological and behavioral responses.
  • To explore the communicative functions of various mouse vocalizations.

Main Methods:

  • Playback experiments using four categories of mouse social vocalizations: ultrasonic vocalizations (USVs), low-frequency harmonic calls, mid-frequency vocalizations, and noisy calls.
  • Measurement of physiological stress responses (corticosterone levels) in male and female mice.
  • Assessment of behavioral changes using open field tests to gauge anxiety-related behaviors.

Main Results:

  • All vocal categories increased stress hormones in females; only non-USV categories affected males, with higher increases in females.
  • All vocal categories reduced central ambulation in both sexes, indicating increased anxiety.
  • Playback affected the proportion of USVs emitted by subjects, suggesting distinct communicative content.

Conclusions:

  • Mouse vocalization categories elicit sex-specific physiological and behavioral responses, even without contextual cues.
  • Different vocal categories appear to possess distinct communicative functions.
  • These findings advance our understanding of the complexity of mouse vocal communication.