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miR-552: an important post-transcriptional regulator that affects human cancer

Yuhao Zou1, Xin Zhao1, Yin Li1

  • 1Medical Genetics Center, Ningbo University School of Medicine, Ningbo, Zhejiang, China.

Journal of Cancer
|October 9, 2020
PubMed

Insights

MicroRNA-552 (miR-552) is upregulated in many cancers and influences tumor progression and drug response. This review explores its diagnostic, prognostic, and therapeutic potential in human cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA-552 (miR-552) is a small non-coding RNA found on chromosome 1p34.3.
  • Its expression is significantly elevated in various tumor tissues and cells.
  • miR-552 targets multiple genes involved in critical cellular processes.

Purpose of the Study:

  • To review the biological functions of miR-552 in human cancer.
  • To summarize the clinical expression patterns of miR-552 in cancer.
  • To explore the potential of miR-552 in cancer diagnosis, prognosis, and treatment.

Main Methods:

  • Literature review of studies on miR-552 in human cancer.
  • Analysis of miR-552's targeted genes and their roles in cancer biology.
  • Examination of miR-552's impact on cancer progression and drug efficacy.

Main Results:

  • miR-552 targets genes regulating transcription, translation, cell cycle, proliferation, apoptosis, migration, and invasion.
  • It influences the efficacy of anticancer drugs by targeting genes like TP53 and RUNX3.
  • Upregulation of miR-552 is a common feature across various human malignancies.

Conclusions:

  • miR-552 plays a significant role in the development and progression of human cancers.
  • Its dysregulation suggests potential as a biomarker for cancer diagnosis and prognosis.
  • Targeting miR-552 may offer novel therapeutic strategies for cancer treatment.
Keywords:
cancerdiagnosisdrug resistancemiR-552prognosis

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