ESHRE PGT Consortium data collection XVI-XVIII: cycles from 2013 to 2015.
E Coonen1,2, A van Montfoort1,2, F Carvalho3,4
1Department of Clinical Genetics, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Human Reproduction Open
|October 9, 2020
Summary
Preimplantation genetic testing (PGT) shows a trend towards trophectoderm biopsy and comprehensive testing for aneuploidies (PGT-A) and structural rearrangements (PGT-SR). These developments reflect advancements in PGT technologies and applications.
Area of Science:
- Reproductive Medicine
- Genetics
- Embryology
Background:
- The ESHRE PGT Consortium has collected international PGT data since 1997.
- Previous data collections have been published, providing a historical overview.
Purpose of the Study:
- To identify trends and developments in preimplantation genetic testing (PGT) between 2013 and 2015.
- To compare these trends with previous years' PGT activities.
Main Methods:
- Retrospective data collection from European PGT centers.
- Voluntary submission of PGT cycle, pregnancy, and baby data using MS Excel tables.
- Exclusion of incomplete or inconsistent data for accurate calculations.
Main Results:
- Increased use of trophectoderm biopsy over cleavage stage biopsy, particularly for PGT-A and PGT-SR.
- Expansion of comprehensive testing technology in PGT-A (66% to 75%) and PGT-SR (36% to 58%).
- Significant number of cycles reported for PGT-A, PGT for monogenic defects, and PGT-SR.
Conclusions:
- The primary trends are increased trophectoderm biopsy and expanded comprehensive testing in PGT-SR and PGT-A.
- Findings represent PGT activity in participating European centers.
- This data collection offers insights into ongoing PGT developments.
Keywords:
PGDPGTaneuploidydata collectionhuman embryomonogenic disorderspreimplantation genetic testingregistrystructural rearrangementsMore Related Videos
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