Related Experiment Video

Updated: Dec 6, 2025

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

401

Multiple flow-related intracranial aneurysms in the setting of contralateral carotid occlusion: Coincidence or

Cassidy Werner1, Mansour Mathkour1, Tyler Scullen1

  • 1Department of Neurosurgery, Tulane Medical Center, New Orleans, LA, USA.

Brain Circulation
|October 9, 2020
PubMed

Insights

Patients with internal carotid artery (ICA) stenosis have a higher risk of developing intracranial aneurysms (IAs), particularly on the opposite side of the stenosis. This suggests altered blood flow dynamics contribute to IA formation.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Radiology

Background:

  • Intracranial aneurysms (IAs) are more common in patients with internal carotid artery (ICA) stenosis.
  • Altered intracranial hemodynamics due to severe ICA stenosis or occlusion may increase contralateral IA risk.

Purpose of the Study:

  • To investigate the association between internal carotid artery stenosis and intracranial aneurysms.
  • To review the pathogenesis and management of flow-related IAs in the context of ICA stenosis.

Main Methods:

  • A case report of a patient with ICA occlusion and multiple aneurysms.
  • A comprehensive literature review of PubMed and EMBASE databases for concurrent IA and ICA stenosis cases.

Main Results:

  • The case patient presented with subarachnoid hemorrhage and multiple aneurysms contralateral to a chronic ICA occlusion.
  • Literature review showed contralateral IAs (25%) were more frequent than ipsilateral IAs (6%) in patients with ICA stenosis.

Conclusions:

  • Contralateral intracranial aneurysms are more prevalent in patients with internal carotid artery stenosis.
  • Altered hemodynamics secondary to ICA stenosis may promote the formation of contralateral IAs.

Keywords:
Carotid stenosisendovascularflow-related aneurysmintracranial aneurysmneurosurgerysubarachnoid hemorrhage

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