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The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
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Interactions among microbes, the immune system, and the circadian clock
John F Brooks1, Lora V Hooper2,3
1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. JohnF.Brooks@utsouthwestern.edu.
Seminars in Immunopathology
|October 9, 2020
Summary
The circadian clock synchronizes immune cell activity with daily light cycles, influencing host defense against pathogens. It also interacts with gut microbiota, impacting immunity and metabolism.
Area of Science:
- Chronobiology
- Immunology
- Microbiology
Background:
- The circadian clock aligns physiological functions with daily light cycles, optimizing energy use and fitness.
- Host immunity is an energy-intensive process involving coordinated immune cell actions against microbes.
- Immune cell development, function, and trafficking are influenced by the circadian clock's entrainment to light cycles.
Purpose of the Study:
- To review the circadian clock's role in regulating host immune responses.
- To explore the impact of commensal and pathogenic microbes on circadian physiology.
Main Methods:
- Literature review of circadian biology and immunology research.
- Analysis of studies on host-microbe interactions and circadian rhythms.
Main Results:
- Circadian clock entrainment leads to daily variations in host susceptibility to pathogens.
- The circadian clock and microbiota engage in bi-directional communication.
- This interaction is crucial for regulating host immunity and metabolism.
Conclusions:
- The circadian clock plays a key role in directing host immune programs.
- Microbial interactions significantly influence circadian rhythms and host defense mechanisms.
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