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Quantification of liver function using gadoxetic acid-enhanced MRI.

Sarah Poetter-Lang1, Nina Bastati1, Alina Messner1

  • 1Department of Biomedical Imaging and Image-Guided Therapy, General Hospital of Vienna (AKH), Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Abdominal Radiology (New York)
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Summary

Gadoxetic acid-enhanced MRI provides functional liver evaluation, aiding in diagnosing chronic liver diseases and monitoring treatment. This technique quanties liver function, improving patient management for various hepatobiliary disorders.

Keywords:
Diffuse liver diseasesGadoxetic acidLiver functionMRIQuantification

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Area of Science:

  • Hepatobiliary imaging
  • Magnetic Resonance Imaging (MRI)

Background:

  • Gadoxetic acid (GA) enables functional hepatobiliary MRI, complementing morphologic assessment.
  • GA uptake involves specific transporters like OATP1,3, MRP2, and MRP3.
  • GA-enhanced MRI is crucial for evaluating chronic liver diseases (CLD), including differentiating NAFLD subtypes and staging fibrosis.

Purpose of the Study:

  • To review the current applications of GA-enhanced MRI in quantifying liver function.
  • To highlight GA-enhanced MRI's role in managing diverse hepatobiliary disorders.

Main Methods:

  • Utilizes gadoxetic acid (GA) as a hepatobiliary contrast agent for MRI.
  • Employs static and dynamic imaging techniques to estimate GA uptake, hepatic extraction fraction (HEF), and liver perfusion.

Main Results:

  • GA-enhanced MRI aids in distinguishing simple steatosis from NASH.
  • It assists in staging liver fibrosis and cirrhosis, predicting transplant graft survival, and assessing resection risks.
  • GA-enhanced MRI is valuable for long-term follow-up and post-treatment monitoring due to its noninvasive nature.

Conclusions:

  • GA-enhanced MRI is a powerful tool for functional liver assessment in various hepatobiliary conditions.
  • Its ability to quantify liver function supports diagnosis, prognosis, and treatment monitoring.