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Updated: Dec 6, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
The study of chiral recognition on ibuprofen enantiomers by a fluorescent probe based on β-cyclodextrin modified
Yanyan Zeng1, Yueting Wang1, Zhihui Liang1
1School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan 523808, China.
Abstract:
In this paper, a fluorescence method for chiral detection of ibuprofen and its enantiomer was developed. The L-cystenine-capped ZnS:Mn quantum dots were synthesized and functionalized with β-cyclodextrin (β-CD-QDs). The β-CD-QDs exhibited different quenching effect to the S-(+)-ibuprofen and the R-(-)-ibuprofen based on the advantage of the inclusion complex of cyclodextrin. It was found that the quenching of β-CD-QDs by S-(+)-ibuprofen was due to the formation of inclusion complex through both static quenching and photoinduced electron transfer, but only slight quenching with the R-(-)-ibuprofen. The stability constants derived from Hildebrand-Benesi method and absorption titration experiments were applied to determine the stability constants of the formed complexes, the double reciprocal plots suggest that a conclusion complex with a ratio of 1:1 was formed between β-CD-QDs and S-(+)-ibuprofen, but did not with the R-(-)-ibuprofen. The fluorescence intensity of the β-CD-QDs was linearly dependent on the concentration of the S-(+)-IBP in the range of 0-0.5 nmol/L with an limit of detection of 0.29 nmol/L.
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