Longitudinal Changes in Resting Metabolic Rates with Aging Are Accelerated by Diseases
Marta Zampino1, Majd AlGhatrif1, Pei-Lun Kuo1
1National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Nutrients
|October 10, 2020
Summary
Aging reduces resting metabolic rate (RMR), with chronic diseases accelerating this decline. Specific conditions like COPD, cancer, diabetes, heart failure, and CKD significantly impact RMR over time.
Area of Science:
- Gerontology
- Metabolic Science
- Chronic Disease Epidemiology
Background:
- Resting metabolic rate (RMR) naturally decreases with age.
- The impact of specific chronic diseases on RMR decline over time is not well understood.
- Aging is associated with changes in health status that may influence metabolic rate.
Purpose of the Study:
- To investigate the association between 15 common age-related chronic diseases and resting metabolic rate (RMR).
- To analyze how specific health impairments influence the longitudinal changes in RMR.
- To explore the relationship between chronic disease status and metabolic rate over a 13-year follow-up period.
Main Methods:
- Analysis of data from 997 participants in the Baltimore Longitudinal Study of Aging.
- Measurement of RMR using indirect calorimetry and body composition via DEXA at each visit.
- Application of linear regression and linear mixed-effect models to assess cross-sectional and longitudinal associations.
Main Results:
- Several chronic diseases were associated with higher RMR at baseline.
- Prevalent COPD and cancer, along with incident diabetes, heart failure, and chronic kidney disease (CKD), were linked to a faster decline in RMR.
- Chronic diseases exhibit a potential two-phase effect on RMR: initial increase followed by a significant decline.
Conclusions:
- Chronic diseases significantly impact the trajectory of RMR decline in aging individuals.
- The findings suggest a complex, potentially biphasic, relationship between chronic disease and metabolic rate.
- Understanding these associations is crucial for managing age-related metabolic changes and disease progression.
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