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Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Related Experiment Video

Updated: Dec 6, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

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Antioxidants as an Epidermal Stem Cell Activator.

Soon-Hyo Kwon1, Kyoung-Chan Park2

  • 1Department of Dermatology, Kyung Hee University Hospital at Gang-dong, Kyung Hee University School of Medicine, Seoul 05278, Korea.

Antioxidants (Basel, Switzerland)
|October 10, 2020
PubMed
Summary

Antioxidants like ascorbic acid and hyaluronic acid can positively impact epidermal stem cells by managing reactive oxygen species and extracellular matrix. This review explores their role in skin regeneration and proliferation in 3D models.

Keywords:
antioxidantsepidermal stem cellextracellular matrixnicheskin equivalent

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Area of Science:

  • Dermatology and Stem Cell Biology
  • Biochemistry and Molecular Biology

Background:

  • Epidermal stem cells reside in a niche crucial for skin regeneration.
  • The stem cell niche microenvironment, including extracellular matrix, influences stem cell behavior.
  • Reactive oxygen species (ROS) and microRNAs play roles in regulating stem cell proliferation.

Purpose of the Study:

  • To review the effects of various antioxidants on the epidermal stem cell niche.
  • To investigate how antioxidants influence the proliferative potential of interfolliclicular epidermal stem cells.
  • To explore the role of antioxidants in 3D skin equivalent models.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of antioxidant mechanisms related to ROS reduction and extracellular matrix regulation.
  • Evaluation of studies using 3D skin equivalent models.

Main Results:

  • Antioxidants can modulate the stem cell niche by reducing ROS production.
  • Certain antioxidants may regulate extracellular matrix protein expression, impacting stem cell behavior.
  • Evidence suggests antioxidants can influence keratinocyte proliferation in 3D models.

Conclusions:

  • Antioxidants represent a promising strategy for modulating epidermal stem cell behavior.
  • Understanding antioxidant effects on the stem cell niche is vital for regenerative dermatology.
  • Further research in 3D models can elucidate antioxidant-mediated skin repair mechanisms.