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Using Aptamers as a Novel Method for Determining GnRH/LH Pulsatility.

Chioma Izzi-Engbeaya1,2, Ali Abbara1,2, Anthony Cass3

  • 1Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.

International Journal of Molecular Sciences
|October 10, 2020
PubMed
Summary

Aptamers offer a novel method for continuous analyte measurement, reducing costs and sampling needs. This technology shows promise for measuring hormones like Gonadotropin-releasing hormone (GnRH) and Luteinizing Hormone (LH) for fertility assessments.

Keywords:
aptamergonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), pulsatilitysynthetic oligonucleotides

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Area of Science:

  • Biotechnology
  • Biochemistry
  • Endocrinology

Background:

  • Aptamers are synthetic DNA/RNA molecules that bind targets, offering alternatives to antibodies.
  • Traditional methods for measuring hormones like GnRH require repeated sampling and are costly.
  • GnRH pulsatility, crucial for fertility, is indirectly assessed via Luteinizing Hormone (LH) pulsatility.

Purpose of the Study:

  • To review the application of aptamers for measuring GnRH and LH.
  • To highlight aptamer technology as a cost-effective and less invasive alternative for hormone monitoring.
  • To discuss the potential of aptamers in portable diagnostic devices.

Main Methods:

  • Review of literature on aptamer development and application for hormone detection.
  • Focus on aptamers designed to bind Gonadotropin-releasing hormone (GnRH) and Luteinizing Hormone (LH).
  • Analysis of aptamer-based detection principles, including conformational changes and signal readouts.

Main Results:

  • Aptamers have been successfully developed to bind and measure both GnRH and LH.
  • Aptamer technology enables continuous analyte monitoring, unlike traditional methods.
  • The adaptability of aptamers makes them suitable for integration into portable diagnostic devices.

Conclusions:

  • Aptamer technology provides a promising approach for the continuous and cost-effective measurement of GnRH and LH.
  • This technology has significant potential for improving fertility assessments and hormone monitoring.
  • The future likely holds wider adoption of aptamer-based diagnostics, particularly in portable applications.