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A comparative perspective on lung and gill regeneration.

Laura Cadiz1, Michael G Jonz2

  • 1Department of Biology, University of Ottawa, 30 Marie Curie Pvt., Ottawa, ON, Canada, K1N 6N5.

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|October 10, 2020
PubMed
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Fish and amphibians can regenerate gills, a process poorly understood despite its long history. Studying gill regeneration in aquatic vertebrates may reveal common signaling pathways for respiratory organ regeneration in all vertebrates, aiding lung repair.

Keywords:
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Area of Science:

  • Comparative biology
  • Regenerative medicine
  • Developmental biology

Background:

  • Gills in fish and amphibians exhibit continuous regeneration, a process not fully understood.
  • Mammalian lungs possess facultative regeneration capabilities, with identified stem/progenitor cells, yet underlying signaling pathways remain unclear.

Purpose of the Study:

  • To explore the evolutionary and embryological links between gills and mammalian lungs.
  • To integrate knowledge on gill and lung regeneration across vertebrates.
  • To highlight aquatic vertebrates as models for respiratory organ regeneration.

Main Methods:

  • Comparative analysis of literature on gill and lung regeneration.
  • Examination of homologies in tissue structure, cell types, function, and genetic pathways.
  • Focus on aquatic vertebrates with high regenerative potential and available genetic tools.

Main Results:

  • Identified shared evolutionary and embryological origins between gills and lungs.
  • Highlighted the potential of aquatic vertebrates to elucidate common regeneration mechanisms.
  • Emphasized the need for further research into gill regeneration signaling pathways.

Conclusions:

  • Gill regeneration in aquatic vertebrates offers a unique model to uncover conserved signaling pathways for respiratory organ regeneration.
  • Understanding these mechanisms could advance tissue repair strategies for lung diseases.
  • A comparative approach is crucial for addressing knowledge gaps in vertebrate respiratory organ regeneration.