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Updated: Dec 6, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Primary Empty Sella.

Sandhya Mehla1, Abigail L Chua1, Brian Grosberg1

  • 1Hartford Healthcare Headache Center, University of Connecticut School of Medicine, West Hartford, CT, USA.

Headache
|October 10, 2020
PubMed
Summary
This summary is machine-generated.

Primary empty sella (PES) is a radiological finding, not a syndrome, and does not cause specific headaches. Endocrine screening may be considered for asymptomatic individuals with PES.

Keywords:
endocrine screeningheadacheprimary empty sella

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Area of Science:

  • Radiology
  • Endocrinology
  • Neuroscience

Background:

  • Primary empty sella (PES) is often mislabeled as a syndrome.
  • It is recognized as a radiological finding rather than a distinct clinical entity.
  • Potential endocrine abnormalities associated with PES warrant further investigation.

Observation:

  • The term "syndrome" for PES is inaccurate.
  • No direct causal link has been established between PES and specific headache types.
  • Asymptomatic individuals with PES may benefit from endocrine evaluation.

Findings:

  • PES is a radiological diagnosis, not a distinct clinical syndrome.
  • Headaches are not a definitive symptom directly attributable to PES.
  • Endocrine screening is a potential consideration for asymptomatic PES cases.

Implications:

  • Clarifies the diagnostic and clinical understanding of Primary Empty Sella.
  • Guides clinical practice regarding headache evaluation in PES patients.
  • Suggests a proactive approach to endocrine health in asymptomatic individuals with PES.