Facilitating smoking cessation using reduced nicotine cigarettes: Intervention development and RCT study design.
Melissa R Conn1, Thomas H Brandon2, Yenis L Lorenzo1
1Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America.
Contemporary Clinical Trials
|October 10, 2020
Summary
This study developed a new smoking cessation program using reduced nicotine cigarettes to aid quitting. The facilitated extinction intervention aims to reduce cravings and improve success rates for smokers.
Area of Science:
- Addiction Medicine
- Behavioral Psychology
- Nicotine Science
Background:
- Nicotine's reinforcing effects hinder smoking cessation.
- Reducing nicotine in cigarettes may facilitate quitting through extinction learning.
- Novel interventions are needed to optimize smoking cessation success.
Purpose of the Study:
- To develop and evaluate a novel facilitated extinction (FE) intervention for smoking cessation.
- To assess the efficacy of reduced nicotine cigarettes in reducing smoking reinforcement.
- To compare FE intervention with standard cognitive-behavioral therapy.
Main Methods:
- Qualitative methods and pilot testing informed FE intervention development.
- A randomized controlled trial (RCT) is evaluating the FE intervention.
- Participants (n=208) are randomized to FE vs. standard intervention and immediate vs. gradual transition to very low nicotine content (VLNC) cigarettes.
Main Results:
- The RCT is ongoing, evaluating the primary aims.
- The study design allows for comparison of different nicotine reduction schedules.
- Participant recruitment and randomization are complete.
Conclusions:
- The FE intervention, utilizing VLNC cigarettes, presents a promising approach to smoking cessation.
- Optimizing extinction learning during a pre-quit period may enhance cessation outcomes.
- Further results from the RCT will determine the intervention's efficacy.
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