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Signalling mechanisms involved in stress response to antifungal drugs

Ján Víglaš1, Petra Olejníková1

  • 1Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 81237, Bratislava, Slovakia.

Research in Microbiology
|October 10, 2020
PubMed

Insights

Antifungal resistance is a growing threat. Fungi adapt to antifungal drugs by evolving conserved molecular mechanisms, offering potential strategies to delay drug resistance development.

Area of Science:

  • Mycology
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Antifungal resistance poses a significant challenge in treating fungal infections (mycoses).
  • Fungal cells can develop resistance upon prolonged exposure to antifungal agents.
  • This exposure induces stress, necessitating adaptive responses from the fungus.

Purpose of the Study:

  • To review conserved molecular mechanisms fungi use to adapt to antifungal-induced stress.
  • To explore the interconnections between these adaptation pathways.
  • To identify potential strategies for delaying antifungal drug resistance.

Main Methods:

  • Literature review of evolutionary conserved molecular mechanisms.
  • Analysis of fungal adaptation responses to antifungal stress.
  • Examination of the interconnection of these mechanisms.

Main Results:

  • Fungi employ evolutionarily conserved molecular pathways to adapt to antifungal stress.
  • These adaptation mechanisms are interconnected.
  • The same core mechanisms are activated irrespective of the specific antifungal agent.

Conclusions:

  • Understanding these conserved mechanisms is key to combating antifungal resistance.
  • Targeting these shared pathways may provide novel strategies to delay resistance.
  • This knowledge can inform the development of new therapeutic approaches against mycoses.
Keywords:
Antifungal drugsHsp90Signalling pathwaysStress adaptationTor kinases

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