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Related Experiment Videos

Does a supernumerary nipple/renal field defect exist?

J H Hersh, A S Bloom, A O Cromer

    American Journal of Diseases of Children (1960)
    |September 1, 1987
    PubMed
    Summary
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    Supernumerary nipple (SNN) presence in patients with genetic or developmental issues may indicate a renal field defect. However, routine urinary tract screening is not recommended for all individuals with SNN.

    Area of Science:

    • Medical Genetics
    • Developmental Biology
    • Urology

    Background:

    • Supernumerary nipple (SNN) has been anecdotally associated with genitourinary anomalies.
    • Previous studies suggested a strong link between SNN and renal abnormalities.

    Purpose of the Study:

    • To investigate the association between supernumerary nipples and renal lesions in patients with suspected genetic and/or developmental problems.
    • To evaluate the clinical significance of SNN as a marker for urinary tract abnormalities.

    Main Methods:

    • A roentgenographic kidney study was performed in 65 patients presenting with suspected genetic and/or developmental issues and a supernumerary nipple.
    • Patient data, including clinical signs, symptoms, and phenotypic abnormalities, were analyzed.

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    Main Results:

    • Seven out of 65 patients (11%) exhibited significant renal lesions, including conjoined kidneys in one case with Fanconi's anemia.
    • Four patients with renal lesions had no prior urinary tract symptoms.
    • The association between SNN and renal defects was weaker than previously reported, with no renal defects observed in Black patients with SNN.

    Conclusions:

    • A potential SNN/renal field defect exists, but its significance is less pronounced than previously suggested.
    • Racial differences and the presence of other minor phenotypic abnormalities may influence this association.
    • An isolated SNN in an otherwise normal individual or in specific malformation patterns does not warrant routine urinary tract diagnostic studies.