Beneficial relevance of vitamin D concentration and urine flow rate

Micturition dysfunction is a problem in the general population that progresses with aging in both males and females. In the past few decades, the relationship between voiding symptoms and body biochemical status has been a subject of research in several disciplines. Micronutrition is considered to affect different aspects of urinary flow, including neuroregulation, detrusor muscle function, and the structures around the bladder outlet such as the pelvic floor and prostate. Therefore, the objective of our study was to determine the correlation between urine flow rate (UFR) and 25-hydroxyvitamin D (25(OH)D) in the general healthy population.

Our study involved 3981 adult participants over age 20 from the U.S. National Health and Nutrition Examination Survey datasets (2011-2012). The associations between UFR and serum 25(OH)D concentration were analyzed through multivariate regression models.

There was a significant positive association of serum 25(OH)D concentration with UFR (25(OH)D₂+25(OH)D₃: β coefficient: 0.003; 95% CI: 0.002, 0.004; p < 0.001, 25(OH)D₃; p = 0.003; epi-25(OH)D₃, p = 0.020) in an unadjusted model. The substantial associations were still observed in the gender and age subgroups. In analysis of age subgroup, the association of serum 25(OH)D concentration with urine flow rate was significant in fully adjusted model (age<60: 25(OH)D₂+25(OH)D₃: β coefficient: 0.004, p < 0.001; 25(OH)D₃: p = <0.001, epi-25(OH)D₃: p = 0.007; Age≥60: 25(OH)D₂+25(OH)D₃: β coefficient: 0.004, p = 0.002; 25(OH)D₃: p = 0.001, epi-25(OH)D₃: p = 0.001). In gender subgroup analysis, the β coefficient of 25(OH)D₂+25(OH)D₃ in male is 0.004 (p < 0.001), and in female is 0.004 (p < 0.001) in fully adjusted model. The higher quartiles of UFR tended to have higher 25(OH)D₃ levels with statistically significant in quartile-based analysis.

UFR was associated with increased level of total vitamin D and bioactive form vitamin D₃. Vitamin D supplements may be a simple and effective way of improving of bladder function.