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Published on: November 28, 2018
Preexisting Right Ventricular Diastolic Dysfunction and Postoperative Cardiac Complications in Patients Undergoing
Alexey N Sumin1, Ekaterina V Korok1, Tatjana Ju Sergeeva1
1Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
Insights
Preoperative right ventricular diastolic dysfunction (RVDD) significantly increases the risk of postoperative heart failure after coronary artery bypass grafting (CABG). Echocardiography can identify patients at higher risk, guiding preventative strategies.
Area of Science:
- Cardiology
- Cardiac Surgery
- Echocardiography
Background:
- Right ventricular diastolic dysfunction (RVDD) is a potential complication in patients undergoing coronary artery bypass grafting (CABG).
- The association between preoperative RVDD and postoperative cardiac complications after CABG requires further investigation.
Purpose of the Study:
- To determine if preexisting RVDD in patients undergoing CABG is linked to a higher incidence of postoperative cardiac complications.
- To identify echocardiographic markers that predict postoperative heart failure (PHF) after CABG.
Main Methods:
- A retrospective cohort study involving 200 patients undergoing CABG.
- Transthoracic echocardiography was used to assess right ventricular (RV) diastolic function parameters.
- Patients were categorized into groups with and without RVDD.
Main Results:
- Patients with RVDD had a significantly higher incidence of postoperative heart failure (PHF) compared to controls (p=0.026).
- Independent predictors of PHF included RVDD (OR 4.82), cardiopulmonary bypass (OR 4.04), and female sex.
- A decreased Et/At ratio was identified as the best echocardiographic predictor of PHF.
Conclusions:
- Preoperative RVDD, cardiopulmonary bypass, and female sex are independent risk factors for PHF post-CABG.
- Echocardiographic assessment of RV diastolic function, particularly the Et/At ratio, can aid in predicting PHF.
- Further studies are needed to confirm the utility of preoperative RV diastolic function assessment for predicting PHF after CABG.
Objectives:
To evaluate whether the presence of preexisting right ventricular diastolic dysfunction (RVDD) in patients undergoing coronary artery bypass grafting (CABG) is associated with a greater incidence of postoperative cardiac complications.
Design:
Single-center, observational, retrospective, cohort study.
Setting:
Research institute hospital.
Participants:
Patients undergoing CABG from February 2017 to November 2018 (n = 200).
Interventions:
None.
Measurements And Main Results:
Transthoracic echocardiography was performed to obtain the following values of right ventricular (RV) diastolic function: peak velocity of early (Et) and late (At) transtricuspid flow, e't, a't, s't, tricuspid annular plane systolic excursion, and the RV Tei index. All patients were divided into the following 2 groups: with RVDD (n = 92) or without RVDD (n = 108). Compared with control patients, the patients with RVDD developed postoperative heart failure (PHF) (primary outcome) more frequently (p = 0.026). RVDD, low left ventricular ejection fraction, were female, underwent cardiopulmonary bypass, increased left ventricular mass index, and an Et/At ratio that increased the risk of the development of PHF. However, only RVDD (odds ratio 4.82; p = 0.015), cardiopulmonary bypass (odds ratio 4.04; p = 0.028), and female sex were associated independently with the development of PHF in the multivariate analyses.
Conclusions:
Preoperative RVDD, cardiopulmonary bypass, and female sex are independent risk factors for the development of PHF after CABG in coronary artery disease patients. The decreased Et/At ratio was the best echocardiographic marker predicting PHF development after CABG. Nevertheless, the possibility of assessing preoperative diastolic RV function to predict the development of PHF after CABG requires confirmation in additional studies.
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