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Twin screw granulation: A simpler re-derivation of quantifying fill level
Aquino L Mundozah1, Jiankai Yang1, Chalak Omar1
1Department of Chemical and Biological Engineering, University of Sheffield, Mapping Street, Sheffield S1 3JD, UK.
International Journal of Pharmaceutics
|October 11, 2020
Summary
A new geometrical model predicts powder fill level in twin-screw granulation (TSG). This model aids in process design and quality control for consistent granule properties across scales.
Area of Science:
- Chemical Engineering
- Materials Science
Background:
- Fill level, the proportion of occupied volume in twin-screw granulators (TSG), is crucial for granule properties.
- Accurate fill level prediction is essential for process design and quality control in TSG.
Purpose of the Study:
- To develop a simple geometrical model for predicting barrel channel fill level in TSG.
- To validate the model through experimental measurement of mass hold-up and assess its impact on granulation.
Main Methods:
- A geometrical model was developed relating volumetric flow rate to screw conveying rate.
- Mass hold-up was analytically measured to validate the predicted fill level.
- The model's correlation with granulation extent was investigated.
Main Results:
- The proposed geometrical model accurately predicts the fill level in TSG.
- Experimental validation using mass hold-up showed good agreement across various screw elements.
- The model offers a practical approach for fill level assessment in TSG.
Conclusions:
- The developed geometrical model provides a reliable method for predicting fill level in twin-screw granulation.
- This model facilitates better process design and control for consistent granule quality.
- The findings contribute to advancing quantitative prediction in TSG processes.
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