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Preterm EEG: A Multimodal Neurophysiological Protocol
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Effects of in-hospital breast feeding on brain function development in preterm infants in China: study protocol for a

Rui Yang1, Yao Zhang2, Hua Wang3

  • 1Nursing Department, Zhejiang University School of Medicine, Hangzhou, China.

BMJ Open
|October 11, 2020
PubMed

Insights

Breastfeeding (BF) significantly impacts preterm infant brain development. This study investigates in-hospital BF

Area of Science:

  • Neonatal Neuroscience
  • Developmental Pediatrics
  • Public Health Nutrition

Background:

  • Preterm infants face higher risks of neurological defects due to immature brain development.
  • While many achieve typical scholastic levels, some experience persistent impairments.
  • Breastfeeding (BF) is a critical public health intervention for preterm infants, with breast milk components supporting brain and central nervous system development.

Purpose of the Study:

  • To prospectively investigate the impact of in-hospital breastfeeding on brain development in preterm infants.
  • To identify potential factors influencing this relationship.
  • To provide evidence-based insights for optimizing infant care and developmental outcomes.

Main Methods:

  • A prospective longitudinal cohort study enrolling 247 preterm infants (30-34 weeks gestational age).
  • Data collection includes demographics, clinical information, in-hospital BF data, and follow-up via phone, interview, or online.
  • Neurodevelopmental assessment using functional near-infrared spectroscopy (fNIRS), Breastfeeding Self-Efficacy Scale-Short Form, extrauterine growth restriction, and Ages and Stages Questionnaire at 3, 6, and 12 months post-birth.

Main Results:

  • Data collection and follow-up procedures are established.
  • The study is designed to yield quantitative and qualitative data on breastfeeding's effects.
  • Specific results regarding neurodevelopmental outcomes and influencing factors will be reported upon study completion.

Conclusions:

  • This study protocol outlines a rigorous approach to understanding breastfeeding's role in preterm infant neurodevelopment.
  • Findings are expected to inform clinical practice and public health strategies.
  • The research aims to enhance long-term outcomes for vulnerable preterm populations.
Abstract

Keywords:
developmental neurology & neurodisabilityneonatal intensive & critical carenutrition & dietetics

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