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Frequency of true hepatitis B virus positivity in blood donors positive for hepatitis B core antibodies: implications
Muniba Kanwal1, Ayesha Junaid1, Naima Tariq2
1Department of Pathology, Shifa International Hospital, Islamabad, Pakistan.
Objective:
To determine the true positivity of hepatitis b virus in anti-hepatitis B core antigen positive donors, keeping polymerase chain reaction as the gold standard.
Methods:
The cross-sectional study was carried out at the Shifa International Hospital, Islamabad, Pakistan, from June 1, 2014, to December 30, 2016, and comprised all blood donors who were positive for hepatitis B core antibody and negative for hepatitis B surface antigenon the basis of by enzyme-linked immunosorbent assay. The smaples were subjected to real-time polymerase chain reaction for hepatitis B deoxyribonucleic acid detection. Data was analysed using SPSS 20.
Results:
All the 100 samples came from males subjects who had a mean age of 36.8±10.8 years. Only 2(2%) donors showed hepatitis B virus deoxyribonucleic acid reactivity.
Conclusion:
The inclusion of Hepatitis B core antibody screening may make blood transfusions safer for the patients.
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