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The functions of EZH2 in immune cells: Principles for novel immunotherapies

Fang-Fei Shao1, Bo-Jin Chen1, Guo-Qing Wu2

  • 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Journal of Leukocyte Biology
|October 11, 2020
PubMed

Insights

Enhancer of zeste homolog 2 (EZH2) plays a key role in cancer development. Targeting EZH2 in immune cells, not just cancer cells, may offer new cancer immunotherapy strategies.

Area of Science:

  • Oncology
  • Immunology
  • Epigenetics

Background:

  • Enhancer of zeste homolog 2 (EZH2) is frequently altered in cancers, suggesting its oncogenic role.
  • EZH2 inhibitors show therapeutic promise, but their mechanisms remain unclear.
  • Previous research focused on EZH2 in cancer cells, failing to explain clinical observations.

Purpose of the Study:

  • To review the emerging roles of EZH2 in various immune cell types.
  • To explore the potential of targeting EZH2 within immune cells for cancer immunotherapy.

Main Methods:

  • Literature review of studies investigating EZH2 in cancer and immune cells.
  • Analysis of EZH2's involvement in immune cell function and cancer-immune interactions.

Main Results:

  • EZH2 influences diverse immune cell populations.
  • EZH2's function in immune cells impacts cancer development and treatment response.
  • Evidence suggests EZH2's role extends beyond cancer cells to modulate the tumor immune microenvironment.

Conclusions:

  • Understanding EZH2's function in immune cells is crucial for advancing cancer therapy.
  • Targeting EZH2 in immune cells presents a promising avenue for novel immunotherapeutic strategies.
  • Further research into EZH2-mediated immune regulation could enhance existing cancer treatments.
Keywords:
EZH2T cell differentiationT cell proliferationtumor immunitytumor microenvironment

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