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Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

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Acromegaly might not negatively affect microvascular circulation.

Yalcin Hacioglu¹, Melike Kalfa², Mutlu Niyazoglu³

¹Department of Family Medicine, Istanbul Teaching and Research Hospital, Istanbul, Turkey.

Internal Medicine Journal

|October 11, 2020

Summary

Patients with acromegaly showed a statistically lower capillary count, but it remained within normal limits. Microvascular circulation and capillary morphology were not significantly impaired in acromegaly patients compared to healthy controls.

Keywords:

acromegaly capillaroscopy capillary microcirculation microvascular

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Area of Science:

Endocrinology
Cardiovascular Science
Microcirculation Research

Background:

Acromegaly is associated with endothelial dysfunction and atherosclerosis.
Limited data exists regarding microvascular circulation changes in acromegaly patients.

Purpose of the Study:

To investigate and evaluate microvascular circulation in individuals with acromegaly.
To compare microvascular parameters between acromegaly patients and healthy controls.

Main Methods:

A comparative study involving 21 acromegaly patients and 20 healthy controls.
Stereomicroscopic evaluation (×100 magnification) of capillary dimensions and count.
Statistical analysis using SPSS 15.0.

Main Results:

The mean capillary count per milliliter was statistically lower in acromegaly patients (7.67 ± 1.88/mL) versus healthy controls (8.67 ± 0.65/mL), P = 0.04.
No significant differences were observed in capillary tortuosity, loop length, or width between the groups.
Although lower, the median capillary count in acromegaly patients was within normal ranges.

Conclusions:

The observed decrease in capillary count in acromegaly patients was not clinically significant and remained within normal limits.
Morphological characteristics of capillaries did not differ between acromegaly patients and healthy controls.
Acromegaly may not lead to microvascular impairment despite known associations with endothelial dysfunction and atherosclerosis.