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Updated: Dec 6, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
COVID-19 pneumonia in an infant with a hemodynamically significant ventricular septal defect
Utkarsh Kohli1, Julia C Rosebush2, Nicola M Orlov3
1Section of Pediatric Cardiology, Department of Pediatrics, Comer Children's Hospital and Pritzker School of Medicine of University of Chicago, Chicago, IL, USA.
Insights
COVID-19 in children with congenital heart disease is not well understood. This case report details a 4-month-old infant with a ventricular septal defect experiencing COVID-19 pneumonia.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Congenital Heart Disease
Background:
- Acute COVID-19 in children is generally mild.
- Limited data exists on COVID-19 in vulnerable pediatric populations, specifically those with congenital heart disease.
Observation:
- A 4-month-old Hispanic male infant presented with COVID-19-associated pneumonia.
- The infant had a moderate-sized conoventricular ventricular septal defect and pulmonary overcirculation.
Findings:
- This case highlights a pediatric patient with complex congenital heart disease affected by COVID-19 pneumonia.
- The clinical course and management of such cases require further investigation.
Implications:
- This case underscores the need for increased awareness and research into COVID-19's impact on infants with hemodynamically significant congenital heart disease.
- Understanding these effects is crucial for developing appropriate clinical guidelines and management strategies for this high-risk group.
Abstract:
Reports thus far suggest a mild course for acute COVID-19 infection in children; however, its effects in vulnerable paediatric populations, including children with haemodynamically significant congenital heart disease, have rarely been reported. We therefore report on a 4-month-old Hispanic male with a moderate sized conoventricular ventricular septal defect and pulmonary overcirculation who presented with COVID-19-associated pneumonia.
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