Tongue-lip adhesion in Pierre-Robin sequence: Role redefined

Veena Singh1, Chandni Sinha2, Nishant Sahay2

  • 1Department of Burns and Plastic Surgery, All India Institute of Medical Sciences, Patna, Bihar, India.

Insights

Tongue-lip adhesion (TLA) offers a simple, effective surgical option for neonatal airway obstruction in Robin sequence. This technique helps manage breathing issues, allowing crucial growth time for affected infants.

Area of Science:

  • Craniofacial Surgery
  • Pediatric Airway Management
  • Neonatal Care

Background:

  • Robin sequence presents a triad of retrognathia, glossoptosis, and airway obstruction, often complicated by mandibular hypoplasia affecting feeding, swallowing, and growth.
  • While nonsurgical methods manage most cases, selected neonates require surgical intervention for survival.
  • Conventional surgical options include tracheostomy, with a shift towards mandibular distraction procedures and, less frequently, tongue-lip adhesion (TLA).

Observation:

  • This case highlights a neonate managed successfully with a simple U-stitch tongue-lip adhesion (TLA), a basic principle of TLA procedures.
  • The U-stitch technique retracts the tongue forward, directly addressing airway obstruction.

Findings:

  • Tongue-lip adhesion (TLA) can be a life-saving intervention for neonatal airway compromise in Robin sequence.
  • The procedure effectively alleviates upper airway obstruction, providing a critical window for mandibular and associated structure development.

Implications:

  • TLA serves as a valuable, potentially less invasive surgical alternative for securing the airway in neonates with Robin sequence.
  • Further research is needed to clarify the comparative efficacy of TLA versus other surgical interventions like mandibular distraction.
  • The choice of surgical procedure should consider available resources and surgeon expertise while prioritizing patient survival and optimal development.

Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.3K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
3.3K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.9K
Tongue01:01

Tongue

The human tongue is a fascinating and complex organ, responsible for various essential functions such as swallowing, speech, and taste. It is also subject to various conditions and diseases. In this article, we delve into the anatomy of the tongue, its roles, and some common conditions that can affect it.
Anatomical Position in the Oral Cavity
The tongue is located within the oral cavity, also known as the mouth. It is attached to the floor of the mouth by a fold of mucous membrane called the...
2.3K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.3K
The Tongue and Taste Buds00:49

The Tongue and Taste Buds

The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
39.9K