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Comparison of four pancreatic extracts in cystic fibrosis
Insights
Creon and Pancrease significantly reduced gastrointestinal symptoms and improved fat absorption in children with cystic fibrosis compared to Pancrex V Forte and Pancreatin Merck. These pancreatic enzyme therapies enable high-energy diets without restrictions.
Area of Science:
- Gastroenterology
- Pediatrics
- Pharmacology
Background:
- Cystic fibrosis (CF) often leads to pancreatic insufficiency.
- Pancreatic enzyme replacement therapy (PERT) is crucial for managing CF-related malabsorption.
- Evaluating the efficacy of different PERT formulations is essential for optimizing patient care.
Purpose of the Study:
- To compare the efficacy of four pancreatin products in children with cystic fibrosis.
- To assess gastrointestinal symptom relief and fat absorption.
- To determine the impact on fecal nitrogen content.
Main Methods:
- Randomized crossover trial involving children with cystic fibrosis.
- Comparison of Pancrease, Creon, Pancrex V Forte, and Pancreatin Merck.
- Evaluation of gastrointestinal symptoms, fat absorption, and fecal nitrogen levels.
Main Results:
- Creon and Pancrease showed fewer gastrointestinal symptoms than Pancrex V Forte and Pancreatin Merck.
- Pancrease significantly improved fat absorption compared to Pancrex V Forte and Pancreatin Merck.
- Creon demonstrated superior fat absorption to Pancrex V Forte; no significant differences were found between Pancrease and Creon.
Conclusions:
- Creon and Pancrease are effective pancreatic enzyme supplements for children with cystic fibrosis.
- These products facilitate improved nutrient absorption and symptom management.
- Patients can adhere to high-energy diets without dietary restrictions when using Creon or Pancrease.
Abstract:
Four different pancreatin products, Pancrease, Creon, Pancrex V Forte, and Pancreatin Merck, were compared in a random crossover trial in children with cystic fibrosis. The results of our study showed that patients who received Creon and Pancrease had fewer gastrointestinal symptoms than patients who received Pancrex V Forte and Pancreatin Merck. Fat absorption was significantly improved with Pancrease when compared with Pancrex V forte and Pancreatin Merck. Also the fat absorption with Creon was superior to that with Pancrex V Forte. There was no significant difference in fat absorption between Pancrease and Creon. Pancrex V Forte and Pancreatin Merck, or Pancreatin Merck and Creon. Faecal nitrogen content was less with both Creon and Pancrease compared with Pancreatin Merck. Creon and Pancrease allow the patient with cystic fibrosis to take a high energy diet without any dietary restrictions.