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Preparation of Functional Silica Using a Bioinspired Method
Published on: August 1, 2018
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In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS-Mediated Anticancer
Ling Li1, Zhen Yang2, Wenpei Fan2
1Department of PET Center, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital,Central South University, Changsha 410008, China.
Advanced Functional Materials
|October 12, 2020
Summary
This study developed a novel nanoreactor combining photodynamic therapy (PDT) and chemodynamic therapy (CDT) to enhance reactive oxygen species (ROS) treatment for pancreatic cancer. The nanoreactor effectively boosts anti-tumor efficacy by generating ROS through synergistic therapeutic approaches.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are promising cancer treatments that rely on reactive oxygen species (ROS).
- Combining PDT and CDT can enhance ROS-mediated cancer treatment, particularly for challenging cancers like pancreatic ductal adenocarcinoma.
- Developing advanced nanocarriers is crucial for integrating these synergistic therapeutic effects.
Purpose of the Study:
- To design and synthesize an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor.
- To integrate photodynamic therapy (PDT) and chemodynamic therapy (CDT) within a single nanoplatform for enhanced pancreatic cancer treatment.
- To improve the generation and delivery of ROS for synergistic anti-tumor effects.
Main Methods:
- Fabrication of HMONs via an in situ framework growth approach, incorporating the HPPH photosensitizer.
- In situ polymerization within HMONs to immobilize glucose oxidase-like gold nanoparticles for self-sufficient H2O2 production.
- Surface modification with Cu2+-tannic acid complexes to catalyze Fenton-like reactions and generate hydroxyl radicals (•OH).
- Loading of collagenase (Col) to degrade extracellular matrix (ECM) for enhanced nanoparticle penetration and oxygen infiltration.
Main Results:
- Successful synthesis of HMON-Au@Cu-TA nanoreactors capable of dual-mode ROS generation.
- Demonstrated synergistic effect of PDT and CDT, leading to enhanced ROS production and anti-tumor activity.
- Improved penetration and oxygen supply within the tumor microenvironment due to collagenase loading.
- Significant enhancement of ROS-mediated anti-tumor efficacy in pancreatic ductal adenocarcinoma models.
Conclusions:
- The developed HMON-based nanoreactor effectively integrates PDT and CDT for synergistic ROS generation.
- This platform offers a promising strategy for enhancing the treatment of pancreatic ductal adenocarcinoma.
- The study provides a valuable paradigm for designing advanced nanotheranostics based on silica nanoparticles.
