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Articles linked to this work by shared authors, journal, and citation graph.

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Differential effects of TRPM4 channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4-chloro-2-[2-(2-chloro-phenoxy)-acetylamino]-benzoic acid (CBA) versus classical 9-phenanthrol.

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Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease.

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Updated: Dec 6, 2025

Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents
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Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function.

John Malysz1, Georgi V Petkov1,2,3

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, United States.

Frontiers in Physiology
|October 12, 2020
PubMed
Summary

Detrusor smooth muscle (DSM) KV7 channels are crucial for bladder function. This review details their role in DSM excitability and contractility, highlighting current knowledge and future research directions.

Keywords:
KCNQcontractilitydetrusorelectrophysiologyexcitabilityoveractive bladderpatch-clampsmooth muscle

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Area of Science:

  • Physiology
  • Pharmacology
  • Urology

Background:

  • Detrusor smooth muscle (DSM) controls the micturition cycle through contraction and relaxation.
  • DSM excitability, crucial for contractility, is regulated by ion channels, particularly K+ channels.
  • Voltage-gated KV7 channels (KV7.1-KV7.5) are emerging regulators in various cell types, with their role in DSM needing further elucidation.

Purpose of the Study:

  • To systematically review the current understanding of KV7 channels in human detrusor smooth muscle (DSM).
  • To highlight recent discoveries regarding KV7 channel expression, function, and modulation in DSM.
  • To identify knowledge gaps and future research priorities for human DSM KV7 channels.

Main Methods:

  • Comprehensive literature review of KV7 channel expression (mRNA and protein) in DSM.
  • Analysis of functional effects of KV7 channel modulators on DSM excitability, contractility, and intracellular Ca2+ dynamics.
  • Inclusion of data from animal models, in vivo studies, and limited human DSM data.

Main Results:

  • KV7 channels are expressed in DSM and influence its excitability and contractility.
  • Selective KV7 channel modulators impact DSM function, affecting Ca2+ dynamics.
  • Significant gaps exist in the systematic study of human DSM KV7 channels.

Conclusions:

  • KV7 channels represent a significant, yet understudied, target for modulating DSM function.
  • Further research, particularly on human DSM, is essential to fully understand KV7 channel roles and therapeutic potential.
  • Ongoing studies aim to resolve critical questions regarding KV7 channel regulation in human bladder physiology.