Related Experiment Video

Updated: Dec 6, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.4K

The Dynamic Interplay Between Cardiac Inflammation and Fibrosis

Toby P Thomas1, Laurel A Grisanti1

  • 1Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.

Frontiers in Physiology
|October 12, 2020
PubMed

Insights

Heart failure, a major global killer, involves cardiac remodeling and fibrosis. This review explores the cellular links between inflammation and fibrosis in heart disease.

Area of Science:

  • Cardiovascular Research
  • Pathophysiology
  • Molecular Biology

Background:

  • Heart failure is a primary cause of global mortality.
  • Cardiac dysfunction arises from remodeling and compliance changes.
  • Fibrosis and inflammation are key contributors to heart failure pathogenesis.

Purpose of the Study:

  • To review the cellular and molecular mechanisms of cardiac inflammation and fibrosis.
  • To elucidate the interplay between inflammatory and fibrotic processes in the heart.

Main Methods:

  • Literature review of cellular and molecular mechanisms.
  • Analysis of the interconnectedness between inflammation and fibrosis.

Main Results:

  • Fibrosis is a common feature across heart failure types.
  • Inflammation plays a critical role in cardiac pathogenesis.
  • Significant interplay exists between cardiac inflammation and fibrosis.

Conclusions:

  • Understanding the inflammation-fibrosis axis is crucial for heart failure treatment.
  • Targeting these pathways may offer novel therapeutic strategies for heart failure.

Keywords:
cardiaccytokinefibroblastfibrosisinflammationleukocyte

More Related Videos

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts07:10

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

5.1K
Isolation of Functional Cardiac Immune Cells07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

15.4K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
220
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
502
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
264
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.4K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
2.0K
Layers of the Heart Wall01:15

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
4.5K