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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
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Sphingolipids in the Heart: From Cradle to Grave
Anna Kovilakath1, Maryam Jamil1, Lauren Ashley Cowart2,3
1Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, United States.
Frontiers in Endocrinology
|October 12, 2020
Summary
Sphingolipids impact heart health, contributing to both cardiovascular disease and protective functions. Research highlights their role in cardiometabolic disease and identifies them as potential biomarkers for cardiovascular disease risk.
Area of Science:
- Biochemistry
- Cardiology
- Metabolomics
Background:
- Cardiovascular diseases (CVD) are a leading global cause of mortality, exacerbated by rising metabolic disease.
- Metabolic disorders disrupt sphingolipid metabolism, implicating them in obesity-related cardiovascular pathology.
- Sphingolipids play dual roles in the heart, mediating both disease processes and essential cardiac functions.
Purpose of the Study:
- To review the dual roles of sphingolipids in cardiogenesis and myocardial function.
- To explore the potential of targeting sphingolipid metabolism for cardiometabolic disease treatment.
- To highlight novel sphingolipid biomarkers for cardiovascular disease risk prediction.
Main Methods:
- Literature review of experimental and lipidomics studies.
- Analysis of sphingolipid metabolism and signaling pathways in cardiovascular contexts.
- Evaluation of sphingolipid biomarkers in cardiovascular disease diagnosis and prognosis.
Main Results:
- Sphingolipids contribute to pathological processes in obesity-related cardiovascular disease.
- Specific sphingolipids are essential for normal cardiac development and function.
- Certain sphingolipids offer protection against ischemia/reperfusion injury.
- Untargeted lipidomics has identified circulating sphingolipids as novel CVD biomarkers.
Conclusions:
- Sphingolipid metabolism is a critical factor in cardiometabolic disease.
- Targeting sphingolipids may offer therapeutic strategies for cardiovascular conditions.
- Circulating sphingolipids show promise as diagnostic and prognostic biomarkers for cardiovascular disease.
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