Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Initiation and promotion in hepatocarcinogenesis.

R Schulte-Hermann

    Archives of Toxicology
    |January 1, 1987
    PubMed
    Summary

    Chemicals initiate liver cancer by altering cells, and phenobarbital promotes tumor growth. This study examines the mechanisms behind these stages of chemical carcinogenesis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Response of liver foci in rats to hepatic tumor promoters.

    Toxicologic pathology·2017
    Same author

    Proliferative liver lesions and sex steroids in rats.

    Toxicologic pathology·2017
    Same author

    Inhibin/activin expression in human and rodent liver: subunits α and βB as new players in human hepatocellular carcinoma?

    British journal of cancer·2011
    Same author

    In vitro studies on subtypes and regulation of active cell death.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Effects of insulin, glucagon and triiodothyronine on DNA synthesis in rat hepatocyte primary cultures induced by liver tumour promoters and EGF.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis.

    British journal of cancer·2008

    Area of Science:

    • Hepatocarcinogenesis research
    • Chemical carcinogenesis mechanisms
    • Toxicology and molecular biology

    Background:

    • Chemical carcinogenesis is a multi-stage process involving initiation and promotion.
    • Genotoxic carcinogens initiate cancer by causing DNA damage, leading to altered hepatocytes in the liver.
    • Phenobarbital is a known promoter of liver tumor development.

    Purpose of the Study:

    • To describe the accelerated growth and phenotypic changes of initiated foci during phenobarbital promotion.
    • To consider the underlying mechanisms of initiation and promotion in chemical carcinogenesis.
    • To elucidate the role of phenobarbital in liver tumor promotion.

    Main Methods:

    • Observation of phenotypically altered hepatocyte foci in the liver.
    • Analysis of accelerated growth kinetics of these foci.
    • Examination of phenotypic alterations during promotion.
    • Mechanistic considerations of initiation and promotion.

    Main Results:

    • Genotoxic carcinogens induce foci of altered hepatocytes (initiation).
    • Phenobarbital accelerates the growth and modifies the phenotype of these initiated foci (promotion).
    • Specific phenotypic changes and growth patterns during promotion were observed.

    Conclusions:

    • Initiation and promotion are critical, distinct stages in liver chemical carcinogenesis.
    • Phenobarbital significantly promotes the development of initiated liver cells into tumors.
    • Understanding these mechanisms is key to preventing and treating liver cancer.

    Related Experiment Videos