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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Related Experiment Video

Updated: Dec 6, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Aortic Arch Calcification and the Risk of Cancer: A Population-Based Cohort Study.

Janine E van der Toorn1,2, Kimberly D van der Willik1,3, Rikje Ruiter1

  • 1Department of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, Netherlands.

Frontiers in Oncology
|October 12, 2020
PubMed
Summary

Individuals with severe aortic arch calcification, a marker of atherosclerosis, face a higher risk of developing cancer. This finding suggests shared risk factors or a potential link between these conditions.

Keywords:
atherosclerosiscalcificationcancercohort studysurvival

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Area of Science:

  • Cardiovascular Medicine
  • Oncology
  • Epidemiology

Background:

  • Atherosclerosis and cancer share common underlying disease pathways.
  • The relationship between atherosclerosis and subsequent cancer risk remains incompletely understood.
  • Aortic arch calcification serves as a reliable indicator of systemic atherosclerosis.

Purpose of the Study:

  • To investigate the association between aortic arch calcification and the risk of developing cancer.
  • To determine if the severity of atherosclerosis, as measured by aortic calcification, correlates with cancer incidence.

Main Methods:

  • Prospective population-based study (Rotterdam Study) with 2,404 participants (mean age 69.5 years).
  • Computed tomography used to quantify aortic arch calcification volume.
  • Participants followed for cancer diagnosis until January 1st, 2015, using Cox proportional hazard models.

Main Results:

  • During a median follow-up of 9.6 years, 348 cancer diagnoses occurred.
  • A higher severity of aortic arch calcification was associated with an increased risk of cancer.
  • The hazard ratio for cancer in the highest tertile of calcification was 1.39 (95% CI = 1.04-1.86).

Conclusions:

  • Severe aortic arch calcification is linked to a significantly higher risk of cancer.
  • This association may be attributed to shared long-term risk factors.
  • The findings suggest a potential co-occurrence or interplay between atherosclerosis and cancer development.