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Molecular Mechanism and Approach in Progression of Meningioma
Zhiwei Shao1, Lihong Liu2, Yanghao Zheng3
1Department of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Abstract:
Meningioma is the most common tumor of the central nervous system, most of which is benign. Even after complete resection, a high rate of recurrence of meningioma is observed. From in-depth study of its pathogenesis, it has been found that a number of chromosomal variations and abnormal molecular signals are closely related to the occurrence and development of malignancy in meningioma, which may provide the theoretical basis and potential direction for accurate and targeted treatment. We have reviewed advances in chromosomal variations and molecular mechanisms involved in the progression of meningioma, and have highlighted the association with malignant biological behavior including cell proliferation, angiogenesis, increased invasiveness, and inhibition of apoptosis. In addition, the chemotherapy of meningioma is summarized and discussed.
Insights
Meningiomas, common brain tumors, often recur after surgery. Understanding their chromosomal variations and molecular changes is key to developing targeted therapies for better outcomes.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Genetics
Background:
- Meningioma is the most common central nervous system tumor, frequently benign but with high recurrence rates even after resection.
- Understanding meningioma pathogenesis is crucial for developing effective treatments.
- Chromosomal variations and molecular signals are implicated in meningioma malignancy.
Purpose of the Study:
- To review advances in chromosomal variations and molecular mechanisms in meningioma progression.
- To highlight the association between molecular alterations and malignant biological behavior.
- To discuss current chemotherapy strategies for meningioma.
Main Methods:
- Literature review of studies on meningioma pathogenesis.
- Analysis of chromosomal variations and molecular signaling pathways.
- Summary of chemotherapy efficacy and challenges.
Main Results:
- Chromosomal variations and abnormal molecular signals correlate with meningioma occurrence and progression.
- These alterations are linked to increased cell proliferation, angiogenesis, invasiveness, and apoptosis inhibition.
- Chemotherapy approaches for meningioma are summarized.
Conclusions:
- Targeted therapies based on identified molecular mechanisms hold promise for meningioma treatment.
- Further research into meningioma genetics and molecular biology is warranted.
- Optimizing chemotherapy regimens remains an important clinical goal.
