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Evaluation of the Storage Stability of Extracellular Vesicles
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Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases.

Yu Liu1, Qiuzi Shen1, Ling Zhang1

  • 1Institute of Reproductive Health and Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Cell and Developmental Biology
|October 12, 2020
PubMed
Summary

Extracellular vesicles (EVs) are crucial for cell communication in health and disease. This review examines their roles in aging and reproductive disorders like PCOS and endometriosis, highlighting their potential as biomarkers.

Keywords:
agingendometriosisextracellular vesiclesisolationpolycystic ovary syndrome

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Reproductive Medicine

Background:

  • Extracellular vesicles (EVs) are key mediators of intercellular communication in physiological and pathological states.
  • Their presence in bodily fluids makes them significant in understanding disease mechanisms.
  • Research into EVs is rapidly evolving, revealing their complex roles.

Purpose of the Study:

  • To systematically review the existence, composition, release, and separation methods of EVs.
  • To explore the potential of EVs in transporting cargos and altering recipient cell functions.
  • To examine the involvement of EVs in aging and reproductive diseases such as polycystic ovary syndrome and endometriosis.

Main Methods:

  • Systematic literature search on extracellular vesicles.
  • Review of evidence on EV existence, composition, and release.
  • Analysis of EV cargos, biomarkers, and separation techniques.

Main Results:

  • EVs play a role in intercellular communication, influencing aging and reproductive diseases.
  • In aging, EVs contribute to inflammatory processes.
  • In polycystic ovary syndrome and endometriosis, EVs are implicated in disease development and serve as potential non-invasive biomarkers.

Conclusions:

  • Extracellular vesicles are integral to intercellular communication, impacting aging and reproductive health.
  • EVs show promise as diagnostic biomarkers and therapeutic targets for diseases like PCOS and endometriosis.
  • Further research is needed to fully elucidate the multifaceted roles of EVs in biological systems.