Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

44.4K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
44.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted neuronal reprogramming rescues memory and neural synchrony in Alzheimer's disease.

Molecular biomedicine·2026
Same author

Teneurin-3 and latrophilin-2 are required for somatotopic map development and somatosensory topognosis.

Current biology : CB·2026
Same author

Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.

Nature communications·2026
Same author

Adhesion G protein-coupled receptors.

Pharmacological reviews·2026
Same author

Teneurin-3 and latrophilin-2 are required for somatotopic map formation and somatosensory topognosis.

bioRxiv : the preprint server for biology·2025
Same author

Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration.

Nature communications·2025

Related Experiment Video

Updated: Dec 6, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.3K

FLRTing Neurons in Cortical Migration During Cerebral Cortex Development.

Claudia Peregrina1,2,3, Daniel Del Toro1,2,3

  • 1Department of Biological Sciences, Faculty of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.

Frontiers in Cell and Developmental Biology
|October 12, 2020
PubMed
Summary

Fibronectin leucine-rich repeat transmembrane proteins (FLRTs) regulate neuronal migration and cortex development. These cell adhesion molecules fine-tune neuron movement, impacting brain structure and function.

Keywords:
FLRTLatrophilinTeneurinUnc5adhesionneuronal migrationrepulsion

More Related Videos

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

7.8K
Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

10.4K

Related Experiment Videos

Last Updated: Dec 6, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.3K
Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

7.8K
Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

10.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Mammalian cerebral cortex development involves neuronal progenitor proliferation and migration.
  • Pyramidal neuron migration occurs along radial glial fibers via radial and tangential movements.
  • Intercellular signaling, including adhesion and repulsion, guides neuronal positioning.

Purpose of the Study:

  • To investigate the role of fibronectin leucine-rich repeat transmembrane proteins (FLRTs) in regulating neuronal migration.
  • To understand how FLRTs influence radial migration and tangential dispersion of neurons.
  • To explore the impact of FLRTs on mammalian cortex morphogenesis.

Main Methods:

  • Structural and functional analyses of FLRTs.
  • Investigation of FLRT interactions with neuronal substrates and guidance cues.
  • Examination of FLRT-mediated cell adhesion and repulsion signaling.

Main Results:

  • FLRTs play a crucial role in regulating both radial and tangential neuronal migration.
  • FLRTs modulate cell adhesion and repulsion through distinct protein complexes.
  • FLRTs interact with multiple receptors involved in axon guidance and synapse formation.

Conclusions:

  • FLRTs are key regulators of neuronal migration essential for cortex morphogenesis.
  • Precise tuning of FLRT-mediated signaling ensures context-dependent neuronal positioning.
  • Understanding FLRT function deepens insights into neural development and circuit formation.