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Fading of Deep Brain Stimulation Efficacy Versus Disease Progression: Untangling a Gordian Knot

Alfonso Fasano1,2,3,4, Marcelo Merello5,6,7

  • 1Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital, UHN Toronto Ontario Canada.

Movement Disorders Clinical Practice
|October 12, 2020
PubMed
Abstract

No abstract available in PubMed .

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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