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Kidney Function Indicators Predict Adverse Outcomes of COVID-19
Ye-Mao Liu1,2, Jing Xie1, Ming-Ming Chen1,2
1Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China.
Med (New York, N.Y.)
|October 12, 2020
Summary
Kidney function markers like BUN and Scr, along with BUA, can predict COVID-19 outcomes. Dynamic changes in these markers, particularly BUN, are associated with disease severity and mortality risk in COVID-19 patients.
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- COVID-19 is a respiratory illness with kidney injury as a known complication.
- The dynamic changes in kidney function and their prognostic implications in COVID-19 patients remain largely uncharacterized.
Purpose of the Study:
- To investigate the dynamic changes in kidney function markers in COVID-19 patients.
- To assess the association between these kidney function changes and COVID-19 prognosis, including severity and mortality.
Main Methods:
- A multicenter retrospective cohort study involving 12,413 COVID-19 patients.
- Patients were stratified into non-severe, severe, and death groups based on outcomes.
- Analysis included clinical characteristics, medical history, laboratory tests, and treatment data.
Main Results:
- Elevated blood urea nitrogen (BUN) and serum creatinine (Scr), and decreased blood uric acid (BUA) were observed at admission in 6.29%, 5.22%, and 11.66% of patients, respectively.
- In patients who died, BUN and Scr levels increased, while BUA levels decreased over 28 days post-admission.
- Higher baseline BUN and Scr, and lower BUA levels were associated with increased all-cause mortality risk.
Conclusions:
- Dynamic changes in BUN, Scr, and BUA are linked to COVID-19 severity and prognosis.
- BUN demonstrates significant potential for predicting adverse outcomes, aiding in severity stratification and triage of COVID-19 patients.
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