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Evaluating medical device and material thrombosis under flow: current and emerging technologies
Jun Ki Hong1, Lingzi Gao, Jasneil Singh
1School of Chemistry, The University of Sydney, NSW 2006, Australia.
Biomaterials Science
|October 12, 2020
Summary
Improving the understanding of blood clot formation on medical devices is crucial. This review examines material thrombosis, blood flow dynamics, and in vitro testing systems to enhance device safety and efficacy.
Area of Science:
- Biomaterials Science
- Medical Device Engineering
- Hematology
Background:
- Blood clot formation (thrombosis) on medical devices causes failure and patient harm.
- Current anti-thrombotic drugs have limitations and bleeding risks.
- Improved understanding of material thrombosis is vital for next-generation devices.
Purpose of the Study:
- To review current knowledge on material thrombosis and blood flow.
- To evaluate in vitro flow systems for thrombogenicity testing.
- To explore technological advancements for improved testing.
Main Methods:
- Literature review of material thrombosis mechanisms.
- Analysis of physical and biological aspects of blood flow.
- Examination of existing in vitro flow systems for thrombogenicity evaluation.
Main Results:
- Material thrombosis is influenced by complex blood flow dynamics.
- Various in vitro flow systems exist with distinct advantages and limitations.
- Advances in technology offer potential for more relevant and accurate testing.
Conclusions:
- Enhanced understanding of material thrombosis is needed for safer medical devices.
- Clinically relevant flow systems are essential for accurate thrombogenicity evaluation.
- Technological innovations will drive improvements in medical device testing and development.
