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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
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Silver nanoparticle in biosensor and bioimaging: Clinical perspectives.

Peng Tan1, HeSheng Li2, Jian Wang3

  • 1Ultrasound Diagnosis Department, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang City, Jiangxi Province, People's Republic of China.

Biotechnology and Applied Biochemistry
|October 12, 2020
PubMed
Summary

Silver nanoparticles (AgNPs) offer unique properties for clinical applications. This review highlights their use in biosensors and bioimaging for disease diagnosis, from molecules to cells.

Keywords:
biomarkerclinical imagingdiagnosismetal nanoparticle

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Nanomaterials with diverse shapes and sizes are increasingly produced through interdisciplinary research.
  • Noble metals like silver (Ag) possess tunable plasmonic properties crucial for various applications.
  • Silver nanoparticles (AgNPs) offer superior thermal/electrical conductivity and electron transfer compared to gold, with enhanced stability.

Purpose of the Study:

  • To review the constructive applications of silver nanoparticles (AgNPs) in biosensors and bioimaging.
  • To explore the potential of AgNPs in diagnosing diseases by detecting various clinical markers.
  • To discuss the use of AgNPs for detecting targets ranging from small molecules to whole cells.

Main Methods:

  • Literature review of recent developments in nanotechnology and nanomaterial synthesis.
  • Analysis of studies focusing on the application of AgNPs in biosensing and bioimaging.
  • Evaluation of AgNP properties relevant to clinical diagnostics and disease detection.

Main Results:

  • AgNPs exhibit unique plasmonic properties, high conductivity, and efficient electron transfer.
  • Modified AgNPs demonstrate enhanced stability in aqueous and ambient environments.
  • AgNPs have shown significant promise in enhancing the specific detection of clinical markers.

Conclusions:

  • Silver nanoparticles are versatile tools with significant potential in diagnosis, drug delivery, environmental applications, electronics, and as antimicrobial agents.
  • The application of AgNPs in biosensors and bioimaging is particularly prominent for disease diagnostics.
  • AgNPs facilitate the detection of a wide range of targets, aiding in the diagnosis of various diseases.