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Elevated postoperative serum uric acid is associated with major adverse events following coronary artery bypass

Ye Shi1, Xiaoqian Zhang1, Juan Du1

  • 1Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal of Cardiac Surgery
|October 12, 2020
PubMed

Insights

Elevated postoperative serum uric acid (SUA) levels after coronary artery bypass grafting (CABG) are linked to worse patient outcomes. Close monitoring of patients with high SUA post-CABG is recommended.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • Limited data exist on the association between postoperative serum uric acid (SUA) and survival after coronary artery bypass grafting (CABG).
  • This study investigates the relationship between postoperative SUA levels and major adverse cardiac and cerebrovascular events (MACCE) in CABG patients.

Purpose of the Study:

  • To evaluate the association between postoperative serum uric acid (SUA) levels and clinical outcomes in patients undergoing coronary artery bypass grafting (CABG).
  • To determine if elevated SUA levels predict adverse events such as mortality, myocardial infarction, stroke, or repeat revascularization after CABG.

Main Methods:

  • A cohort of 1614 patients undergoing CABG between 2011 and 2015 was analyzed.
  • Patients were stratified into quartiles based on postoperative SUA levels (measured 6-18 hours post-surgery).
  • The association between SUA quartiles and MACCE, including mortality/myocardial infarction, was assessed using multivariable regression models.

Main Results:

  • Higher quartiles of postoperative SUA were significantly associated with increased in-hospital MACCE (OR: 2.40) and mortality/MI (OR: 2.88).
  • Elevated postoperative SUA was independently associated with MACCE (HR: 1.70) and mortality/MI (HR: 2.42) within 3 years post-CABG.
  • The study included patients with a mean age of 60.3 years, 79.3% male, with a mean follow-up of 2.5 years.

Conclusions:

  • Elevated postoperative serum uric acid levels are a significant predictor of poor clinical outcomes following CABG.
  • Patients exhibiting high postoperative SUA levels after CABG warrant close clinical observation and management.
Abstract

Keywords:
coronary artery bypass graftingmajor adverse cardiac and cerebrovascular eventsmortalitypostoperative uric acid

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