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Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?
British Journal of Clinical Pharmacology
|July 1, 1987
Summary
Ketotifen did not significantly inhibit bronchoconstriction caused by isocapnic hyperventilation in asthma patients. This 12-week study found no difference compared to placebo, suggesting limited efficacy for this specific asthma symptom.
Area of Science:
- Pulmonology
- Clinical Pharmacology
Background:
- Asthma is a chronic respiratory disease characterized by airway inflammation and hyperresponsiveness.
- Isocapnic hyperventilation (IH) is a common method to assess exercise-induced bronchoconstriction in asthma.
Purpose of the Study:
- To evaluate the efficacy of ketotifen in preventing bronchoconstriction induced by isocapnic hyperventilation (IH) in patients with asthma.
- To compare the effects of ketotifen versus placebo on airway hyperresponsiveness to IH.
Main Methods:
- A 12-week, double-blind, placebo-controlled study involving eight asthmatic patients.
- Patients received ketotifen (1 mg twice daily) or placebo.
- Bronchoconstriction was measured following IH challenges after the treatment period.
Main Results:
- No statistically significant difference was observed in the degree of bronchoconstriction induced by IH between the ketotifen and placebo groups.
- Ketotifen did not demonstrate a significant inhibitory effect on IH-induced bronchoconstriction.
Conclusions:
- Ketotifen, at the tested dosage and duration, was not effective in inhibiting bronchoconstriction induced by isocapnic hyperventilation in this cohort of asthma patients.
- Further research may be needed to explore other dosages or patient populations.
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