Calcitonin suppresses gastric emptying of a radiolabelled solid meal in humans

The effects on gastric emptying of calcitonin/i.v. 1.5 i.u. kg-1 body mass bolus or 10 i.u. followed by infusion to overall 1.5 i.u. kg-1 body mass dose vs placebo were studied in four healthy volunteers and in four patients with an active peptic ulcer. Gastric emptying of a radiolabelled solid meal was surveyed. Pronounced delay in gastric emptying was observed in all studied subjects, mean transit time MTT90 calcitonin 39.2 +/- 0.85 min vs placebo 32.8 +/- 1.31 min, P less than 0.001.