Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

1.5K
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
1.5K
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

1.3K
Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
1.3K
Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

502
Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
502
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

2.0K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
2.0K
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

1.0K
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
1.0K
Gas Chromatography: Sample Injection Systems01:08

Gas Chromatography: Sample Injection Systems

1.1K
In gas chromatography, the sample is introduced as a vapor plug into the carrier gas stream for high efficiency and resolution. A microsyringe injects the sample solution into a heated sample port, vaporizing it and mixing it with the carrier gas. This process is important to ensure the sample is properly prepared for analysis. Thermally sensitive samples can be injected directly into the column and volatilized by slowly increasing the column temperature.
Two primary injection methods are used...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urinary Iodine Quantification in Epidemiological Studies: Optimization in Sample Preparation of the Sandell-Kolthoff Method.

ACS omega·2026
Same author

Phenotyping and Selection of Cells Using Mass Spectrometry and a Microfluidic Droplet Printer.

Analytical chemistry·2025
Same author

ReferenceRangeR: a novel tool designed to facilitate reference interval estimation and verification.

Clinical chemistry and laboratory medicine·2025
Same author

Smoking Topography, Nicotine Kinetics, and Subjective Smoking Experience of Mentholated and Non-Mentholated Heated Tobacco Products in Occasional Smokers.

Toxics·2025
Same author

Characteristics of a tattooed population and a possible role of tattoos as a risk factor for chronic diseases: Results from the LIFE-Adult-Study.

PloS one·2025
Same author

Disposable e-cigarettes and their nicotine delivery, usage pattern, and subjective effects in occasionally smoking adults.

Scientific reports·2025

Related Experiment Video

Updated: Dec 6, 2025

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

11.6K

Versatile Dual-Inlet Sample Introduction System for Multi-Mode Single Particle Inductively Coupled Plasma Mass

Daniel Rosenkranz1, Fabian L Kriegel2, Emmanouil Mavrakis3

  • 1Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR); daniel.rosenkranz@bfr.bund.de.

Journal of Visualized Experiments : Jove
|October 12, 2020
PubMed
Summary
This summary is machine-generated.

A new dual-inlet setup for single-particle inductively coupled plasma mass spectrometry (spICP-MS) enables accurate nanoparticle characterization without reference materials. This method improves size and number concentration measurements for various metal nanoparticles.

More Related Videos

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS
11:18

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS

Published on: July 11, 2017

11.0K
Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
05:48

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry

Published on: September 5, 2014

9.9K

Related Experiment Videos

Last Updated: Dec 6, 2025

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

11.6K
A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS
11:18

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS

Published on: July 11, 2017

11.0K
Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
05:48

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry

Published on: September 5, 2014

9.9K

Area of Science:

  • Analytical Chemistry
  • Nanotechnology
  • Materials Science

Background:

  • Metal-containing nanoparticles (NP) are typically characterized using single-particle inductively coupled plasma mass spectrometry (spICP-MS).
  • Accurate quantification of NP size and number concentration relies heavily on instrument setup, operational conditions, and user-defined parameters.
  • Current limitations include the scarcity of NP reference materials, leading to potential biases in size and number concentration measurements.

Purpose of the Study:

  • To develop and validate a dual-inlet setup for spICP-MS to overcome the limitations of NP reference materials.
  • To enable accurate characterization of nanoparticle size and number concentration independent of NP reference standards.
  • To improve the sensitivity and lower the detection limits for NP analysis.

Main Methods:

  • A novel dual-inlet system was designed, integrating a pneumatic nebulizer (PN) for NP solutions and a microdroplet generator (µDG) for ionic calibration solutions.
  • A flexible interface allowed for simultaneous calibration, NP characterization, and system cleaning while the ICP-MS instrument was operational.
  • Three independent analysis modes were employed: Mode I (counting), Mode II (sensitivity-based transport efficiency determination using ionic standards), and Mode III (µDG).

Main Results:

  • The developed dual-inlet setup successfully characterized nanoparticles (Au, Ag, CeO2) without the need for NP reference materials.
  • Mode II provided a method to determine transport efficiency using only inorganic ionic standards, independent of NP reference materials.
  • The µDG-based inlet system achieved superior analyte sensitivities, resulting in size-dependent detection limits below 15 nm for investigated NPs.

Conclusions:

  • The novel dual-inlet setup offers a robust and flexible solution for accurate nanoparticle quantification using spICP-MS.
  • This approach eliminates the dependency on limited NP reference materials, reducing measurement bias.
  • The system's enhanced sensitivity and low detection limits broaden the scope for characterizing nanoparticles in various applications.