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Updated: Dec 6, 2025
06:58
Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
Published on: October 7, 2021
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A cellular handbook for collided ribosomes: surveillance pathways and collision types
Sezen Meydan1,2, Nicholas R Guydosh3
1National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive Room 220, Bethesda, MD, 20892, USA.
Current Genetics
|October 12, 2020
Summary
Ribosome collisions on messenger RNAs (mRNAs) are common in cells and are detected by cellular pathways. These events can influence protein production and cell stability.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Ribosomes stall on mRNA obstacles, leading to collisions (disomes, trisomes).
- The prevalence and detection of these collisions on endogenous mRNAs were unclear.
Purpose of the Study:
- To review recent findings on identifying endogenous ribosome collisions.
- To discuss cellular pathways that sense collision severity.
- To explore the role of collided ribosomes in cellular processes.
Main Methods:
- Genome-wide surveys of ribosome collisions.
- Analysis of cellular surveillance pathways.
- Investigation of ribosome stalling context and duration.
Main Results:
- Widespread distribution of disomes and trisomes across endogenous mRNAs in eukaryotes.
- Collision recognition and response depend on stalling context and duration.
Conclusions:
- Ribosome collisions are a common cellular event.
- Cellular pathways are dedicated to sensing collision severity.
- Collided ribosomes may modulate co-translational events and cellular homeostasis.
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