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A Method for the Stereoselective Construction of the Hemiaminal Center in Zampanolides
Tobias M Brütsch1, Simone Berardozzi1, Marlene L Rothe1
1Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Abstract:
We have developed a new method for the stereoselective establishment of the N-acyl hemiaminal moiety in zampanolide-type structures that involves the reaction of (Z,E)-sorbamide (3) with BINAL-H and subsequent amide transfer from a putative aluminum carboximidoate complex to the aldehyde moiety of a dactylolide precursor, such as 2 or 5. The method has enabled the efficient synthesis of 13-desmethylene-(-)-zampanolide (4), which was found to be an equipotent cell growth inhibitor as the natural product (-)-zampanolide (1).
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