Hydrosulfide Oxidation at a Molybdenum Tetrasulfido Complex
Tobias J Sherbow1, Lev N Zakharov1, Darren W Johnson1
1Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1253, United States.
Inorganic Chemistry
|October 12, 2020
Summary
Hydrogen sulfide (H2S) oxidation by a molybdenum complex generates reactive sulfur species. This study reveals new pathways for metal-mediated signaling and protein persulfidation.
Area of Science:
- Biochemistry
- Inorganic Chemistry
- Chemical Biology
Background:
- Hydrogen sulfide (H2S) is a crucial gasotransmitter involved in cellular signaling.
- Oxidation of H2S leads to reactive sulfur species (RSS) essential for protein persulfidation.
Purpose of the Study:
- To investigate the direct reaction between a molybdenum tetrasulfide complex and hydrosulfide.
- To explore novel H2S oxidation pathways and RSS generation mechanisms.
Main Methods:
- Reaction of [NBu4][TpMoS(S4)] with [NBu4][SH] to form polysulfides.
- Utilizing benzyl bromide (BnBr) as a trapping agent to confirm polysulfide formation.
Main Results:
- A molybdenum tetrasulfide complex directly reacts with hydrosulfide to yield polysulfides.
- Trapping experiments confirmed the generation of polysulfides, indicated by the formation of Bn2S2.
- The molybdenum center was observed to undergo oxidation during the reaction.
Conclusions:
- This research presents new reaction pathways for H2S oxidation and RSS generation.
- Metal-bound polysulfides can serve as a source of RSS, expanding the understanding of biological signaling.
- The findings highlight the potential role of metals in biological signaling processes involving sulfur species.
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