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Pentosan Polysulfate Maculopathy: What Urologists Should Know in 2020
Jan Alberto Paredes Mogica1, Elise J B De2
1Anahuac University, Naucalpan de Juárez, Mexico.
Urology
|October 12, 2020
Summary
Pentosan Polysulfate Sodium, an oral treatment for interstitial cystitis, may be associated with an increased risk of developing macular disease after prolonged use. Further research and regular eye exams are recommended for patients on this medication.
Area of Science:
- Ophthalmology
- Pharmacology
- Urology
Background:
- Pentosan Polysulfate Sodium is the sole oral FDA-approved medication for interstitial cystitis.
- The potential ocular side effects of this medication have not been extensively studied.
Purpose of the Study:
- To systematically review existing literature to determine if Pentosan Polysulfate Sodium is associated with the development of macular disease.
- To assess the risk of maculopathy in patients using Pentosan Polysulfate Sodium for interstitial cystitis.
Main Methods:
- A systematic literature review was performed using databases such as PubMed, Ovid, Medline, EBSCO, and Google Scholar.
- Search terms included "Pentosan Polysulfate Maculopathy," "Pentosan Polysulfate Retinopathy," and "Interstitial Cystitis Maculopathy."
- All papers reporting primary data were included in the review.
Main Results:
- Fourteen papers reporting primary data were identified and reviewed.
- The majority of studies indicated macular disease development in patients with chronic Pentosan Polysulfate Sodium exposure.
- No randomized controlled trials were found, and data were insufficient for meta-analysis.
Conclusions:
- Current data suggest a potential increased risk of maculopathy with long-term Pentosan Polysulfate Sodium use.
- Given the potential risks and marginal effectiveness, patient education on this association is advised.
- Regular ophthalmic evaluations are recommended for patients on chronic Pentosan Polysulfate Sodium therapy.
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