Fertility outcome after Intracytoplasmic Sperm Injection with surgically retrieved sperm

Area of Science:

• Reproductive Medicine
• Andrology
• Infertility Treatment

Background:

• Intra Cytoplasmic Sperm Injection (ICSI) and surgically retrieved sperm are crucial for treating severe male factor infertility, including azoospermia.
• Testicular sperm extraction provides a viable option for sperm retrieval in such cases.

Purpose of the Study:

• To evaluate the clinical pregnancy and live birth rates using sperm obtained from testicular biopsies.
• To assess secondary outcomes such as fertilization and implantation rates in ICSI cycles.

Main Methods:

• A retrospective descriptive study of ICSI cycles utilizing surgically retrieved sperm.
• Data collected from January 2015 to December 2018 at Nîmes University Hospital.
• Analysis of clinical pregnancy, fertilization, implantation, and live birth rates.

Main Results:

• 164 ICSI cycles were performed using surgically collected sperm.
• Clinical pregnancy rate was 37% (47/127) and live birth rate was 35.4% (45/127) from fresh embryo transfers.
• Average fertilization rate was 45% and implantation rate was 23.7%.

Conclusions:

• Testicular sperm extraction with ICSI is an effective treatment for male infertility associated with azoospermia or severe semen alterations.
• This technique provides a valuable opportunity for couples to achieve parenthood using their own gametes.