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Spectrin expression during mammalian brain ontogeny.

I S Zagon, B M Riederer, S R Goodman

    Brain Research Bulletin
    |June 1, 1987
    PubMed
    Summary
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    Two brain spectrin subtypes show distinct developmental patterns. Brain spectrin (240/235) is present early, while brain spectrin (240/235E) emerges postnatally, suggesting specific roles in neurodevelopment.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Cell Biology

    Background:

    • Mammalian brains contain at least two distinct spectrin subtypes: brain spectrin (240/235) and brain spectrin (240/235E).
    • Understanding the differential expression of these subtypes during brain development is crucial for comprehending neuro-ontogeny.

    Purpose of the Study:

    • To review and present evidence on the differential expression of brain spectrin subtypes during mouse brain development.
    • To discuss the potential functional roles of these spectrin subtypes in neurodevelopment.

    Main Methods:

    • Review of existing evidence on spectrin subtype expression.
    • Immunological detection using antibodies specific to red blood cell spectrin for brain spectrin (240/235E).

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    Main Results:

    • Brain spectrin (240/235) is detected in fetal brain, increases during development, and is enriched in cortical germinative neural cells and axonal fibers.
    • Brain spectrin (240/235E) is undetectable in fetal/neonatal brains, increases postnatally, and localizes to neurons and glial cells (excluding mitotic cells), notably in cerebellar and dentate gyrus granule cells.

    Conclusions:

    • Brain spectrin (240/235) and brain spectrin (240/235E) exhibit distinct spatio-temporal expression patterns during mouse brain development.
    • These differential expression profiles suggest specialized functions for each spectrin subtype in neuro-ontogeny, particularly in neuronal differentiation and maturation.