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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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LncExpDB: an expression database of human long non-coding RNAs.

Zhao Li1,2,3,4, Lin Liu1,2,3,4, Shuai Jiang1,2,3

  • 1China National Center for Bioinformation, Beijing 100101, China.

Nucleic Acids Research
|October 12, 2020
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Summary
This summary is machine-generated.

LncExpDB is a new database offering comprehensive expression profiles for human long non-coding RNAs (lncRNAs). It aids in understanding lncRNA functions, interactions, and reliability across diverse biological conditions.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Long non-coding RNAs (lncRNAs) play crucial roles in biological processes.
  • Understanding lncRNA expression patterns is vital for elucidating their functions.
  • A centralized resource for human lncRNA expression data is currently lacking.

Purpose of the Study:

  • To develop LncExpDB, a comprehensive database for human lncRNA expression profiles.
  • To systematically characterize the expression landscape of human lncRNAs.
  • To facilitate the identification of functional lncRNAs and their interactions.

Main Methods:

  • Integrated expression profiles from diverse biological conditions.
  • Stringent data curation and quality control.
  • Development of user-friendly web interfaces for data exploration.

Main Results:

  • LncExpDB houses expression data for 101,293 human lncRNA genes from 1977 samples across 337 conditions.
  • Identified 25,191 featured lncRNA genes with potentially important functions.
  • Cataloged 28,443,865 lncRNA-mRNA interactions.

Conclusions:

  • LncExpDB provides a comprehensive and curated resource for human lncRNA expression.
  • The database enables exploration of lncRNA expression features, reliability, and interactions.
  • LncExpDB serves as a fundamental resource for advancing human lncRNA functional studies.