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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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What are Proteins?01:28

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Proteins are polymers of amino acids linked together by peptide bonds. Proteins and polypeptides are interchangeably used to refer to long chains of amino acids. However, polypeptides have a molecular weight of fewer than 10,000 daltons, while proteins have greater molecular weight.  Polypeptides with less than 20 amino acids are called oligopeptides or simply peptides. Interactions among the constituent amino acid side chains of proteins help them fold into a stable 3-dimensional...
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What are Proteins?01:55

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Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

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Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan...
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Types of Hormones01:21

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Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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Peptide and pseudo-peptide.

Siroos Mirzaei1, Rainer W Lipp2

  • 1Department of Nuclear Medicine with PET-Center, Wilhelminenspital, Vienna, Austria - siroos.mirzaei@wienkav.at.

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of
|October 13, 2020
PubMed
Summary
This summary is machine-generated.

Prostate-specific membrane antigen (PSMA) theranostic twins, using 64Cu/18F for PET-CT imaging and 177Lu for therapy, show promise for diagnosing and treating metastatic prostate cancer. This approach enhances patient selection and therapy response evaluation.

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Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiopharmaceutical Therapy

Background:

  • Theranostic twins have emerged as a significant advancement in nuclear medicine for targeted diagnosis and treatment.
  • Neuroendocrine tumors have benefited from theranostic approaches, paving the way for new applications.

Purpose of the Study:

  • To introduce 64Cu/18F labeled prostate specific membrane antigen (PSMA) for PET-CT imaging and 177Lu labeled PSMA inhibitors for peptide radioligand therapy as the next theranostic twins.
  • To highlight the diagnostic capabilities of PSMA PET/CT in detecting metastatic prostate cancer and guiding therapy.
  • To explore the potential of 64Cu-labeled radiopharmaceuticals for imaging and assessing treatment response.

Main Methods:

  • Utilizing 64Cu/18F labeled PSMA for Positron Emission Tomography-Computed Tomography (PET-CT) imaging.
  • Employing 177Lu labeled PSMA inhibitors for peptide radioligand therapy.
  • Investigating 64Cu-somatostatin analogs as additional imaging tools.

Main Results:

  • 64Cu/18F PSMA PET/CT demonstrates high sensitivity and specificity in detecting metastatic prostate cancer.
  • PSMA PET/CT is effective in patient selection for radioligand therapy and in evaluating treatment outcomes.
  • 64Cu-labeled radiopharmaceuticals show promise in assessing primary disease, recurrence, and therapy response.

Conclusions:

  • 64Cu/18F labeled PSMA theranostic twins are poised to become a cornerstone in nuclear medicine for prostate cancer management.
  • The long half-life of 64Cu facilitates broader access to PET imaging through satellite distribution.
  • PSMA-based theranostics offer a comprehensive strategy for diagnosis, patient selection, and treatment monitoring in prostate cancer.